產(chǎn)品名稱：Bortezomib

產(chǎn)品描述：蛋白酶體抑制劑

產(chǎn)品貨號：SIH-328

純度：>98%

CAS號：179324-69-7

分子式：C19H25BN4O4

分子量：384.2

產(chǎn)品特性

儲存溫度：-20oC

運輸溫度：常溫運輸

產(chǎn)品類型：抑制劑

溶解性：溶解于DMSO (50mg/mL), 乙醇 (35mg/mL )

來源：合成的

性狀：白色粉末

SMILES：B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O

InChIInChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1

InChIKey：GXJABQQUPOEUTA-RDJZCZTQSA-N

安全術語：安全級別: 注意: 物質尚未充分測試. 安全術語: S22 -不要吸入粉塵 S36/37/39 - 穿戴適當?shù)姆雷o服、手套和眼睛/面部保護 S24/25- 避免皮膚和眼睛接觸

引用該產(chǎn)品：Bortezomib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-328)

生物學特性

別名：Bortezomib, 保特佐米, B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; Velcade; Radiciol

研究領域：癌癥, 細胞凋亡, 腫瘤生長抑制劑, 蛋白酶體抑制劑

PubChem ID：387447

科研背景：Potent and selective proteasome inhibitor (Ki=0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50=7 nM). Inhibits TNF synthesis and FGF-induced angiogenesis. Reversible. Cell permeable.

參考資料：1. Adams J., et al. (1999) Cancer Res. 59: 2615. 2. Williams S., et al. (2003) Mol. Cancer Ther. 2: 835.

訂購詳情

文獻引用

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Dieude, M. et al. (2019) Am J Transpl 20(3):726-738.

PubMed ID: 31729155 應用范圍: In vitro inhibition

The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection

Dieude, M. et al. (2019) Sci Transl Med 7(318)

PubMed ID: 26676607 應用范圍: In vitro inhibition

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