in vivo PD-L1 blockade Immunofluorescence Immunohistochemistry (frozen) Flow cytometry Western blot
產品形式
PBS, pH 6.5,Contains no stabilizers or preservatives
純度
>95%, Determined by SDS-PAGE
聚合
<5%, Determined by SEC
無菌處理
0.2 µm filtration
純化方式
Protein G
RRID
AB_10949073
分子量
150 kDa
小鼠病原檢測
Ectromelia/Mousepox Virus: Negative
Hantavirus: Negative
K Virus: Negative
Lactate Dehydrogenase-Elevating Virus: Negative
Lymphocytic Choriomeningitis virus: Negative
Mouse Adenovirus: Negative
Mouse Cytomegalovirus: Negative
Mouse Hepatitis Virus: Negative
Mouse Minute Virus: Negative
Mouse Norovirus: Negative
Mouse Parvovirus: Negative
Mouse Rotavirus: Negative
Mycoplasma Pulmonis: Negative
Pneumonia Virus of Mice: Negative
Polyoma Virus: Negative
Reovirus Screen: Negative
Sendai Virus: Negative
Theiler’s Murine Encephalomyelitis: Negative
保存條件
抗體原液保存在4°C，不能冷凍保存。
推薦同型對照
InVivoPlus rat IgG2b isotype control, anti-keyhole limpet hemocyanin（貨號BP0090）
推薦抗體稀釋液
InVivoPure pH 6.5 Dilution Buffer（貨號IP0065）
為什么選擇InVivoPlus抗體？
InVivoPlus級別的產品內毒素含量更低，經過多種實驗驗證，更適合用于體內實驗研究
該產品自上市已被多篇SCI文獻引用，品質有保證，以下是部分已發(fā)表的文獻引用：
應用
文章
體內PD-L1阻斷
(in vivo PD-L1 blockade)
1. Grasselly, C., et al. (2018). 'The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent' Front Immunol 9: 2100.
2. Stathopoulou, C., et al. (2018). 'PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells' Immunity 49(2): 247-263 e247.
3. Kim, J., et al. (2015). 'Memory programming in CD8(+) T-cell differentiation is intrinsic and is not determined by CD4 help' Nat Commun 6: 7994.
體內PD-L1阻斷，流式細胞術
(in vivo PD-L1 blockade, Flow Cytometry)
1. Aloulou, M., et al. (2016). 'Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells' Nat Commun 7: 10579.
2. Ngiow, S. F., et al. (2015). 'A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1' Cancer Res 75(18): 3800-3811.
3. Rutigliano, J. A., et al. (2014). 'Highly pathological influenza A virus infection is associated with augmented expression of PD-1 by functionally compromised virus-specific CD8+ T cells' J Virol 88(3): 1636-1651.
體內PD-L1阻斷，免疫熒光
(in vivo PD-L1 blockade, Immunofluorescence)
1.Willimsky, G., et al. (2013). 'Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance' J Clin Invest 123(3): 1032-1043.
1.Riella, L. V., et al. (2011). 'Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts' Am J Transplant 11(4): 832-840.
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