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      技術文章您現(xiàn)在的位置：首頁 > 技術文章 > BioXCell欣博盛生物：RecombiMAb anti-mouse CTLA-4 (CD152)
       
      
      
        
      BioXCell欣博盛生物：RecombiMAb anti-mouse CTLA-4 (CD152)
      
        
      更新時間：2023-09-28      點擊次數(shù)：522次
      
        
      BioXCell產(chǎn)品--RecombiMAb anti-mouse CTLA-4 (CD152)
       
      產(chǎn)品描述：
      9D9-CP006單克隆抗體是原始9D9單克隆抗體的重組嵌合型抗體?？勺兘Y構域序列與原始9D9克隆號相同，但是恒定區(qū)序列已經(jīng)從小鼠IgG2b變?yōu)樾∈驣gG1。9D9-CP006單克隆抗體能與小鼠CTLA-4(細胞毒性T淋巴細胞抗原-4)反應，CTLA-4也稱為CD152。CTLA-4是一種33 kDa的細胞表面受體，由屬于免疫球蛋白超家族CD28家族的Ctla4基因編碼。CTLA-4在活化的T淋巴細胞和B淋巴細胞上表達。CTLA-4在結構上類似于T細胞共刺激蛋白CD28，兩種分子都與B7家族成員B7-1 (CD80)和B7-2 (CD86)結合。在與配體結合時，CTLA-4負調(diào)節(jié)細胞介導的免疫反應。CTLA-4在誘導和/或維持免疫耐受、胸腺細胞發(fā)育和保護性免疫調(diào)節(jié)中起作用。CTLA-4在免疫下調(diào)中的關鍵作用已經(jīng)在CTLA-4缺陷小鼠中得到證實，這些小鼠在3-5周齡時由于淋巴增生性疾病的發(fā)展而死亡。CTLA-4是目前腫瘤免疫檢查點治療的熱門靶點之一。
       
      產(chǎn)品詳情：
      產(chǎn)品名稱
      RecombiMAb anti-mouse CTLA-4 (CD152)
      產(chǎn)品貨號
      CP006
      產(chǎn)品規(guī)格
      1mg
      反應種屬
      Mouse
      克隆號
      9D9-CP006
      同種型
      Mouse IgG1(switched from mouse IgG2b)
      免疫原
      Not available or unknown
      實驗應用
      in vivo CTLA-4 neutralization*
      Western blot*
      *Reported for the original mouse IgG2b 9D9 antibody
      產(chǎn)品形式
      PBS, pH 7.0,Contains no stabilizers or preservatives
      純度
      >95%, Determined by SDS-PAGE
      聚合
      <5%, Determined by SEC
      無菌處理
      0.2 µm filtration
      純化方式
      Protein G
      分子量
      150 kDa
      小鼠病原檢測
      Ectromelia/Mousepox Virus: Negative
      Hantavirus: Negative
      K Virus: Negative
      Lactate Dehydrogenase-Elevating Virus: Negative
      Lymphocytic Choriomeningitis virus: Negative
      Mouse Adenovirus: Negative
      Mouse Cytomegalovirus: Negative
      Mouse Hepatitis Virus: Negative
      Mouse Minute Virus: Negative
      Mouse Norovirus: Negative
      Mouse Parvovirus: Negative
      Mouse Rotavirus: Negative
      Mycoplasma Pulmonis: Negative
      Pneumonia Virus of Mice: Negative
      Polyoma Virus: Negative
      Reovirus Screen: Negative
      Sendai Virus: Negative
      Theiler’s Murine Encephalomyelitis: Negative
      保存條件
      抗體原液保存在4°C，不能冷凍保存。
      推薦同型對照
      InVivoPlus mouse IgG1 isotype control, unknown specificity（貨號BP0083）
      推薦抗體稀釋液
      InVivoPure pH 7.0 Dilution Buffer（貨號IP0070）
       
      該產(chǎn)品自上市已被多篇SCI文獻引用，品質(zhì)有保證，以下是部分已發(fā)表的文獻引用：
      應用
      文章
      體內(nèi)CTLA-4中和
      (in vivo CTLA-4 
      neutralization)
      1. Dai, M., et al. (2015). 'Curing mice with large tumors by locally delivering 
      combinations of immunomodulatory antibodies' Clin Cancer Res 21(5): 1127-1138.
      2. Zippelius, A., et al. (2015). 'Induced PD-L1 expression mediates acquired 
      resistance to agonistic anti-CD40 treatment' Cancer Immunol Res 3(3): 236-244.
      3. Redmond, W. L., et al. (2014). 'Combined targeting of costimulatory (OX40) 
      and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of 
      driving robust antitumor immunity' Cancer Immunol Res 2(2): 142-153.
      4. Condamine, T., et al. (2014). 'ER stress regulates myeloid-derived suppressor 
      cell fate through TRAIL-R-mediated apoptosis' J Clin Invest 124(6): 2626-2639.
      5. Muller, P., et al. (2014). 'Microtubule-depolymerizing agents used in antibody-drug 
      conjugates induce antitumor immunity by stimulation of dendritic cells' Cancer Immunol 
      Res 2(8): 741-755.
      6. Bulliard, Y., et al. (2013). 'Activating Fc gamma receptors contribute to the antitumor 
      activities of immunoregulatory receptor-targeting antibodies' J Exp Med 210(9): 1685-1693.
       
       
       
      BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CTLA-4 (CD152)
      更多產(chǎn)品詳情請聯(lián)系 BioXCell 中國授權代理——欣博盛生物