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    1. 技術文章您現(xiàn)在的位置:首頁 > 技術文章 > BioXCell欣博盛生物:RecombiMAb anti-mouse CTLA-4 (CD152)

      BioXCell欣博盛生物:RecombiMAb anti-mouse CTLA-4 (CD152)

      更新時間:2023-09-28   點擊次數(shù):522次

      BioXCell產(chǎn)品--RecombiMAb anti-mouse CTLA-4 (CD152)

       

      產(chǎn)品描述:

      9D9-CP006單克隆抗體是原始9D9單克隆抗體的重組嵌合型抗體??勺兘Y構域序列與原始9D9克隆號相同,但是恒定區(qū)序列已經(jīng)從小鼠IgG2b變?yōu)樾∈驣gG1。9D9-CP006單克隆抗體能與小鼠CTLA-4(細胞毒性T淋巴細胞抗原-4)反應,CTLA-4也稱為CD152。CTLA-4是一種33 kDa的細胞表面受體,由屬于免疫球蛋白超家族CD28家族的Ctla4基因編碼。CTLA-4在活化的T淋巴細胞和B淋巴細胞上表達。CTLA-4在結構上類似于T細胞共刺激蛋白CD28,兩種分子都與B7家族成員B7-1 (CD80)和B7-2 (CD86)結合。在與配體結合時,CTLA-4負調(diào)節(jié)細胞介導的免疫反應。CTLA-4在誘導和/或維持免疫耐受、胸腺細胞發(fā)育和保護性免疫調(diào)節(jié)中起作用。CTLA-4在免疫下調(diào)中的關鍵作用已經(jīng)在CTLA-4缺陷小鼠中得到證實,這些小鼠在3-5周齡時由于淋巴增生性疾病的發(fā)展而死亡。CTLA-4是目前腫瘤免疫檢查點治療的熱門靶點之一。

       

      產(chǎn)品詳情:

      產(chǎn)品名稱

      RecombiMAb anti-mouse CTLA-4 (CD152)

      產(chǎn)品貨號

      CP006

      產(chǎn)品規(guī)格

      1mg

      反應種屬

      Mouse

      克隆號

      9D9-CP006

      同種型

      Mouse IgG1(switched from mouse IgG2b)

      免疫原

      Not available or unknown

      實驗應用

      in vivo CTLA-4 neutralization*

      Western blot*

      *Reported for the original mouse IgG2b 9D9 antibody

      產(chǎn)品形式

      PBS, pH 7.0,Contains no stabilizers or preservatives

      純度

      >95%, Determined by SDS-PAGE

      聚合

      <5%, Determined by SEC

      無菌處理

      0.2 µm filtration

      純化方式

      Protein G

      分子量

      150 kDa

      小鼠病原檢測

      Ectromelia/Mousepox Virus: Negative

      Hantavirus: Negative

      K Virus: Negative

      Lactate Dehydrogenase-Elevating Virus: Negative

      Lymphocytic Choriomeningitis virus: Negative

      Mouse Adenovirus: Negative

      Mouse Cytomegalovirus: Negative

      Mouse Hepatitis Virus: Negative

      Mouse Minute Virus: Negative

      Mouse Norovirus: Negative

      Mouse Parvovirus: Negative

      Mouse Rotavirus: Negative

      Mycoplasma Pulmonis: Negative

      Pneumonia Virus of Mice: Negative

      Polyoma Virus: Negative

      Reovirus Screen: Negative

      Sendai Virus: Negative

      Theiler’s Murine Encephalomyelitis: Negative

      保存條件

      抗體原液保存在4°C,不能冷凍保存。

      推薦同型對照

      InVivoPlus mouse IgG1 isotype control, unknown specificity(貨號BP0083)

      推薦抗體稀釋液

      InVivoPure pH 7.0 Dilution Buffer(貨號IP0070)

       

      該產(chǎn)品自上市已被多篇SCI文獻引用,品質(zhì)有保證,以下是部分已發(fā)表的文獻引用:

      應用

      文章

      體內(nèi)CTLA-4中和

      (in vivo CTLA-4 

      neutralization)

      1. Dai, M., et al. (2015). 'Curing mice with large tumors by locally delivering 

      combinations of immunomodulatory antibodies' Clin Cancer Res 21(5): 1127-1138.

      2. Zippelius, A., et al. (2015). 'Induced PD-L1 expression mediates acquired 

      resistance to agonistic anti-CD40 treatment' Cancer Immunol Res 3(3): 236-244.

      3. Redmond, W. L., et al. (2014). 'Combined targeting of costimulatory (OX40) 

      and coinhibitory (CTLA-4) pathways elicits potent effector T cells capable of 

      driving robust antitumor immunity' Cancer Immunol Res 2(2): 142-153.

      4. Condamine, T., et al. (2014). 'ER stress regulates myeloid-derived suppressor 

      cell fate through TRAIL-R-mediated apoptosis' J Clin Invest 124(6): 2626-2639.

      5. Muller, P., et al. (2014). 'Microtubule-depolymerizing agents used in antibody-drug 

      conjugates induce antitumor immunity by stimulation of dendritic cells' Cancer Immunol 

      Res 2(8): 741-755.

      6. Bulliard, Y., et al. (2013). 'Activating Fc gamma receptors contribute to the antitumor 

      activities of immunoregulatory receptor-targeting antibodies' J Exp Med 210(9): 1685-1693.

       

       

       

      BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse CTLA-4 (CD152)

      更多產(chǎn)品詳情請聯(lián)系 BioXCell 中國授權代理——欣博盛生物