A lipid-soluble neurotoxin that acts as a sodium channel modulator. Binds with high affinity to the open state of the voltage-sensitive sodium channels at site 2, thereby causing a persistent ……
A lipid-soluble neurotoxin that acts as a sodium channel modulator. Binds with high affinity to the open state of the voltage-sensitive sodium channels at site 2, thereby causing a persistent activation of the sodium channels, which become refractory to excitation.
Soluble in 100% ethanol (35mg/ml); almost insoluble in water (0.3mg/ml).
Shipping:
Ambient
Long Term Storage:
+4°C
Handling:
Protect from light.
Regulatory Status:
RUO - Research Use Only
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Product Literature References
Non-quantal acetylcholine release at mouse neuromuscular junction: effects of elevated quantal release and aconitine: S.P. Yu & W. Van der Kloot; Neurosci. Lett. 117, 111 (1990), Abstract;
Synthesis and activity of a potent N-methyl-D-aspartic acid agonist, trans-1-aminocyclobutane-1,3-dicarboxylic acid, and related phosphonic and carboxylic acids: M. Muroi, et al.; Neuropharmacology 29, 567 (1990), Abstract;
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