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      MDP

      更新時間:2022-01-29

      簡要描述:

      Muramyl dipeptide (MDP) is the minimal bioactive peptidoglycan motif common to all bacteria, the essential structure required for adjuvant activity in vaccines.
      MDP has been shown to be recognized by…

      型號:廠商性質(zhì):代理商瀏覽量:773

      NOD2 Agonist - Muramyldipeptide (L-D isomer, active)

      Muramyl dipeptide (MDP) is the minimal bioactive peptidoglycan motif common to all bacteria, the essential structure required for adjuvant activity in vaccines.

      MDP has been shown to be recognized by NOD2, but not TLR2, nor TLR2/1 or TLR2/6 associations [1, 2]. This recognition is highly stereospecific of the L-D isomer, excluding any reaction to the D-D or L-L analogs [2].

      The potent adjuvant activity of MDP may be linked to an activation of the CIAS1/NALP3/Cryopyrin inflammasome [3].

       

      References:

      1. Girardin SE. et al., 2003. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem. 278(11):8869-72.
      2. Inohara N. et al., 2003. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.J Biol Chem. 278(8):5509-12.
      3. Martinon F. et al., 2004. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol. 14(21):1929-34.


      Specifications

      Specificity: NOD2 agonist

      Working concentration: 10 ng - 10 µg/ml

      CAS number: 53678-77-6

      Solubility: 10 mg/ml in water

      Formula: C19H32N4O11

      Molecular weight: 492.5

      Synonym: N-Acetylmuramyl-L-Alanyl-D-Isoglutamine (L-D isoform)


      Contents

      MDP is provided as a lyophilized powder.

      • 5 mg Muramyl dipeptide (MDP)

      • 2 ml sterile endotoxin-free water

      room temperature MDP is shipped at room temperature.

      store Store at -20°C. Upon resuspension, aliquote MDP and store at -20°C. 

      stable Product is stable 6 months at -20°C when properly stored.

      Alert Avoid repeated freeze-thaw cycles.


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