Methylated deoxycytidine analogs are well studied epigenetic modifications. 5-Hydroxymethyl-2'-deoxycytidine has recently been discovered in mammalian genomic DNA, but is substantially depleted in ma…
Methylated deoxycytidine analogs are well studied epigenetic modifications. 5-Hydroxymethyl-2'-deoxycytidine has recently been discovered in mammalian genomic DNA, but is substantially depleted in many types of human cancers. A strong inverse relationship has been demonstrated between the proliferation rate of cells and the global level of 5-hydroxymethyl-2'-deoxycytidine in both porcine and rat tissues, but no such relationship was observed for 5-formyl-2'-deoxycytidine and 5-carboxyl-2'-deoxycytidine.
Product Details
Catalog NoN-2060
Purity≥90% by AX-HPLC
Extinction Coefficient7,700 Lmol-1cm-1 at 275 nm
Molecular FormulaC10H18N3O14P3 (free acid)
Molecular Weight497.10 g/mole (free acid)
Salt FormLi+
Concentration100 mM
BufferH2O
Recommended Storage-20°C or below
Other Name(s)5-hme-dCTP, 5-hmdCTP, 5-Hydroxymethyl-dCTP
ApplicationAptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies
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