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    1. 技術(shù)文章您現(xiàn)在的位置:首頁(yè) > 技術(shù)文章 > RecombiMAb anti-mouse VEGFR-2抗體

      RecombiMAb anti-mouse VEGFR-2抗體

      更新時(shí)間:2023-10-31   點(diǎn)擊次數(shù):496次

      產(chǎn)品描述:

      DC101-CP132單克隆抗體是原始DC101單克隆的重組嵌合型抗體??勺兘Y(jié)構(gòu)域序列與原始DC101相同,但是恒定區(qū)序列已經(jīng)從大鼠IgG1變?yōu)樾∈驣gG2a。DC101-CP132單克隆抗體像原始大鼠IgG1抗體一樣,不包含F(xiàn)c突變。

       

      DC101-CP132單克隆抗體能與小鼠VEGFR-2(血管內(nèi)皮生長(zhǎng)因子受體2)反應(yīng),VEGFR-2也稱為CD309、KDR和Flk-1。VEGFR-2是酪氨酸蛋白激酶家族的成員。當(dāng)結(jié)合到其配體血管內(nèi)皮生長(zhǎng)因子時(shí)發(fā)揮生理作用,血管內(nèi)皮生長(zhǎng)因子受體-2在血管發(fā)育和通透性中起關(guān)鍵作用。血管內(nèi)皮生長(zhǎng)因子受體-2在成人心臟、肺、腎、腦和骨骼肌的內(nèi)皮細(xì)胞中高表達(dá),在其他組織中低表達(dá)。DC101單克隆抗體已被證明在體內(nèi)抑制VEGFR-2信號(hào)傳導(dǎo)。

      BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse VEGFR-2

       

      產(chǎn)品詳情:

      產(chǎn)品名稱

      RecombiMAb anti-mouse VEGFR-2

      產(chǎn)品貨號(hào)

      CP132

      產(chǎn)品規(guī)格

      1/5/25/50/100mg

      反應(yīng)種屬

      Mouse

      克隆號(hào)

      DC101-CP132

      同種型

      Mouse IgG2a(switched from rat IgG1)

      免疫原

      Mouse VEGFR-2-SEAPs soluble receptor

      實(shí)驗(yàn)應(yīng)用

      in vivo blocking of VEGF/VEGFR-2 signaling*
      in vitro blocking of VEGFR signaling*
      Western blot*
      *Reported for the original rat IgG1 DC101 antibody

      產(chǎn)品形式

      PBS, pH 7.0,Contains no stabilizers or preservatives

      純度

      >95%, Determined by SDS-PAGE

      聚合

      <5%, Determined by SEC

      無(wú)菌處理

      0.2 µm filtration

      純化方式

      Protein G

      分子量

      150 kDa

      小鼠病原檢測(cè)

      Ectromelia/Mousepox Virus: Negative

      Hantavirus: Negative

      K Virus: Negative

      Lactate Dehydrogenase-Elevating Virus: Negative

      Lymphocytic Choriomeningitis virus: Negative

      Mouse Adenovirus: Negative

      Mouse Cytomegalovirus: Negative

      Mouse Hepatitis Virus: Negative

      Mouse Minute Virus: Negative

      Mouse Norovirus: Negative

      Mouse Parvovirus: Negative

      Mouse Rotavirus: Negative

      Mycoplasma Pulmonis: Negative

      Pneumonia Virus of Mice: Negative

      Polyoma Virus: Negative

      Reovirus Screen: Negative

      Sendai Virus: Negative

      Theiler’s Murine Encephalomyelitis: Negative

      保存條件

      抗體原液保存在4°C,不能冷凍保存。

      推薦同型對(duì)照

      InVivoPlus mouse IgG2a isotype control, unknown specificity(貨號(hào)BP0085)

      推薦抗體稀釋液

      InVivoPure pH 7.0 Dilution Buffer(貨號(hào)IP0070)

       

       

       

       

      該產(chǎn)品自上市已被多篇SCI文獻(xiàn)引用,品質(zhì)有保證,以下是部分已發(fā)表的文獻(xiàn)引用:

      應(yīng)用

      文章

      體內(nèi)VEGF/VEGFR-2信號(hào)阻斷

      (in vivo blocking of VEGF/VEGFR-2 signaling)

      1. Ding, X., et al. (2015). 'Distinct functions of epidermal and myeloid-derived VEGF-A in skin tumorigenesis mediated by HPV8' Cancer Res 75(2): 330-343.

      2. Lee, H. J., et al. (2015). 'Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1alpha maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature' Int J Radiat Oncol Biol Phys 91(3): 621-630.

      3. Arulanandam, R., et al. (2015). 'VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection' Cancer Cell 28(2): 210-224.

      4. Kizhatil, K., et al. (2014). 'Schlemm’s canal is a unique vessel with a combination of blood vascular and lymphatic phenotypes that forms by a novel developmental process' PLoS Biol 12(7): e1001912.

      體內(nèi)VEGF/VEGFR-2信號(hào)阻斷,體外VEGFR信號(hào)阻斷

      (in vivo blocking of VEGF/VEGFR-2 signaling, in vitro blocking of VEGFR signaling)

      1.Larrayoz, M., et al. (2014). 'Contrasting responses of non-small cell lung cancer to antiangiogenic therapies depend on histological subtype' EMBO Mol Med 6(4): 539-550.  

       

       

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