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      技術(shù)文章您現(xiàn)在的位置：首頁 > 技術(shù)文章 > BioXCell產(chǎn)品介紹--RecombiMAb anti-mouse PD-L1 (B7-H1) (D265A)
       
      
      
        
      BioXCell產(chǎn)品介紹--RecombiMAb anti-mouse PD-L1 (B7-H1) (D265A)
      
        
      更新時間：2023-10-31      點擊次數(shù)：564次
      
        
      BioXCell熱銷產(chǎn)品--RecombiMAb anti-mouse PD-L1 (B7-H1) (D265A)
       
      產(chǎn)品描述：
      10F.9G2™-CP001單克隆抗體是原始10F.9G2™單克隆抗體的重組嵌合型抗體?？勺兘Y(jié)構(gòu)域序列與原始10F.9G2™克隆號相同，但是恒定區(qū)序列已經(jīng)從大鼠IgG2b變?yōu)樾∈驣gG1。10F.9G2™-CP001單克隆抗體在Fc片段中也含有D265A突變，使其無法與內(nèi)源性Fcγ受體結(jié)合。
       
      10F.9G2™-CP001單克隆抗體與小鼠PD-L1（程序性死亡配體1，也稱為B7-H1或CD274）反應(yīng)。PD-L1是屬于Ig超家族的B7家族的I型跨膜蛋白，分子量為40kDa。PD-L1在T淋巴細胞、B淋巴細胞、NK細胞、樹突狀細胞以及IFNγ刺激的單核細胞、上皮細胞和內(nèi)皮細胞上表達。PD-L1與CD4和CD8胸腺細胞以及活化的T和B淋巴細胞和骨髓細胞上的受體PD-1結(jié)合。PD-L1與PD-1的結(jié)合導(dǎo)致抑制TCR介導(dǎo)的T細胞增殖和細胞因子產(chǎn)生。PD-L1被認(rèn)為在腫瘤免疫逃逸中起著重要作用。誘導(dǎo)的PD-L1表達在許多腫瘤中很常見，并導(dǎo)致腫瘤細胞對CD8+ T細胞介導(dǎo)的裂解的抗性增加。在黑色素瘤的小鼠模型中，可以通過用阻斷PD-L1和PD-1之間相互作用的抗體進行治療，暫時抑制腫瘤生長。10F.9G2™單克隆抗體已被證明可以阻斷PD-L1和PD-1之間以及PD-L1和B7-1之間的相互作用（CD80）。
       
      產(chǎn)品詳情：
      產(chǎn)品名稱
      RecombiMAb anti-mouse PD-L1 (B7-H1) (D265A) /欣博盛生物
      產(chǎn)品貨號
      CP001
      產(chǎn)品規(guī)格
      1mg
      反應(yīng)種屬
      Mouse
      克隆號
      10F.9G2™-CP001
      同種型
      Mouse IgG1(switched from rat IgG2b)
      免疫原
      Mouse CD274
      實驗應(yīng)用
      in vivo PD-L1 blockade*
      Immunofluorescence*
      Immunohistochemistry (frozen)*
      Flow cytometry*
      Western blot*
      *Reported for the original rat IgG2b 10F.9G2 antibody
      產(chǎn)品形式
      PBS, pH 7.0,Contains no stabilizers or preservatives
      純度
      >95%, Determined by SDS-PAGE
      聚合
      <5%, Determined by SEC
      無菌處理
      0.2 µm filtration
      純化方式
      Protein A
      分子量
      150 kDa
      小鼠病原檢測
      Ectromelia/Mousepox Virus: Negative
      Hantavirus: Negative
      K Virus: Negative
      Lactate Dehydrogenase-Elevating Virus: Negative
      Lymphocytic Choriomeningitis virus: Negative
      Mouse Adenovirus: Negative
      Mouse Cytomegalovirus: Negative
      Mouse Hepatitis Virus: Negative
      Mouse Minute Virus: Negative
      Mouse Norovirus: Negative
      Mouse Parvovirus: Negative
      Mouse Rotavirus: Negative
      Mycoplasma Pulmonis: Negative
      Pneumonia Virus of Mice: Negative
      Polyoma Virus: Negative
      Reovirus Screen: Negative
      Sendai Virus: Negative
      Theiler’s Murine Encephalomyelitis: Negative
      保存條件
      抗體原液保存在4°C，不能冷凍保存。
      推薦抗體稀釋液
      InVivoPure pH 7.0 Dilution Buffer（貨號IP0070）
       
      該產(chǎn)品自上市已被多篇SCI文獻引用，品質(zhì)有保證，以下是部分已發(fā)表的文獻引用：
      應(yīng)用
      文章
      體內(nèi)PD-L1阻斷
      (in vivo PD-L1 blockade)
      1. Grasselly, C., et al. (2018). 'The Antitumor Activity of Combinations of Cytotoxic 
      Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent' Front 
      Immunol 9: 2100.

      2. Stathopoulou, C., et al. (2018). 'PD-1 Inhibitory Receptor Downregulates Asparaginyl 
      Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory 
      T Cells' Immunity 49(2): 247-263 e247.

      3. Jaworska, K., et al. (2015). 'Both PD-1 ligands protect the kidney from ischemia 
      reperfusion injury' J Immunol 194(1): 325-333.

      4. Kim, J., et al. (2015). 'Memory programming in CD8(+) T-cell differentiation is 
      intrinsic and is not determined by CD4 help' Nat Commun 6: 7994.

      5. Zander, R. A., et al. (2015). 'PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk 
      Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity' Cell 
      Host Microbe 17(5): 628-641.
      體內(nèi)PD-L1阻斷，流式細胞術(shù)
      (in vivo PD-L1 blockade, Flow 
      Cytometry)
      1. Aloulou, M., et al. (2016). 'Follicular regulatory T cells can be specific for the 
      immunizing antigen and derive from naive T cells' Nat Commun 7: 10579.

      2. Ngiow, S. F., et al. (2015). 'A Threshold Level of Intratumor CD8+ T-cell PD1 
      Expression Dictates Therapeutic Response to Anti-PD1' Cancer Res 75(18): 3800-3811.

      3. Rutigliano, J. A., et al. (2014). 'Highly pathological influenza A virus infection is 
      associated with augmented expression of PD-1 by functionally compromised 
      virus-specific CD8+ T cells' J Virol 88(3): 1636-1651.
      體內(nèi)PD-L1阻斷，免疫熒光
      (in vivo PD-L1 blockade, 
      Immunofluorescence)
      1.Willimsky, G., et al. (2013). 'Virus-induced hepatocellular carcinomas cause 
      antigen-specific local tolerance' J Clin Invest 123(3): 1032-1043.
      免疫組織化學(xué)（冷凍），免疫熒光
      (Immunohistochemistry (frozen), 
      Immunofluorescence)
      1.Riella, L. V., et al. (2011). 'Essential role of PDL1 expression on nonhematopoietic 
      donor cells in acquired tolerance to vascularized cardiac allografts' Am J Transplant 
      11(4): 832-840.
       
       
       
       
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