The JES5-2A5 monoclonal antibody reacts with mouse IL-10. IL-10 is a 17-21 kDa cytokine which is primarily produced by monocytes and, to a lesser extent, Th2 cells, mast cells, T regulatory cells, and
The JES5-2A5 monoclonal antibody reacts with mouse IL-10. IL-10 is a 17-21 kDa cytokine which is primarily produced by monocytes and, to a lesser extent, Th2 cells, mast cells, T regulatory cells, and certain subsets of activated T and B cells. IL-10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggest that this cytokine is an essential immunoregulator in the intestinal tract. The JES5-2A5 antibody has been shown to neutralize the bioactivity of natural or recombinant IL-10.
產(chǎn)品名稱:InVivoMab anti-mouse IL-10
反應(yīng)種屬:mouse
宿主來源:rat
實(shí)驗應(yīng)用:in vivo IL-10 neutralization, in vitro IL-10 neutralization
同種型:IgG1, κ
免疫原:Recombinant mouse IL-10
克隆性:Monoclonal
克隆號:JES5-2A5
產(chǎn)品濃度:Lot specific,typically between 4-11 mg/ml
保存溫度:Undiluted at 4°C in the dark
運(yùn)輸溫度:Ship with adequate amount of blue ice to ensure the product remains at 4°C for the duration of transit
預(yù)期分子量:150 kDa
產(chǎn)品形式:液體
有效期:One year from the date of receipt if stored as recommended
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