Isolated from human plasma that is tested to be negative for HbsAg, anti-HBc, anti-HCV, and anti-HIV-1 and -2.
UniProt ID:
P01023
Shipping:
Shipped on Blue Ice
Long Term Storage:
-20°C
Scientific Background:
In addition to binding TGF-β and β-amyloid, α2-macroglobulin covalently binds and inhibits a wide range of proteases, including ADAMs, calpains, cathepsins, chymase, clotting factors, kallikreins, MMPs, neutrophil elastase, and proteinase 3. It also plays a role in the innate immune system, inhibiting parasitic proteases. When treated with methylamine, it blocks binding of apoE to lipoprotein receptor-related protein (LRP).
Regulatory Status:
RUO - Research Use Only
Product Literature References
Cytotoxicity mechanism of α-MMC in normal liver cells through LRP1 mediated endocytosis and JNK activation: L. Wang, et al.; Toxicology 357, 33 (2016), Abstract;
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